| Cellular nutrition
| SuperMide™ patent [In Stock, Ready to Ship]
Spermidine
Spermidine
- To give you a more cost-effective shopping experience, we have chosen a higher-value shipping method. Delivery is expected in up to about 20 days. Thank you for your understanding and patience.
- Additional customs duties may apply once the product arrives in the United States.
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2 capsules/day
As Low as
88.00 HKD/month
The following content is a scientific introduction to ingredient knowledge, representing only the effects of nutritional components and not serving as an introduction to the product's effects.
Scientific Evidence

Higher spermidine intake correlates with better cognition in mild-to-moderate dementia; mild cases benefit most.

Age-related spermidine decline impacts immunity; supplementation revives immune vigor via autophagy, translation and mitochondrial metabolism.

Randomized trial shows spermidine improves memory in elderly with cognitive decline, likely through neuromodulation.

In Dahl, salt-sensitive rats fed a high-salt diet, spermidine supplementation reduced systemic blood pressure and prevented cardiac hypertrophy and diastolic dysfunction, thereby delaying the progression to concentric heart failure. Data assessment indicates that high dietary levels of spermidine in humans are associated with lower blood pressure and a reduced incidence of cardiovascular disease.

Spermidine can upregulate the expression of epithelial stem cell-related keratins K15 and K19, as well as key target genes in human scalp hair follicles (HF) such as POP3 (which regulates cell adhesion and migration), SYVN1, NACA, and SLC25A3 (involved in endoplasmic reticulum and mitochondrial function). This demonstrates that spermidine is a potent stimulant for human hair growth and a modulator of human epithelial stem cell biology.
Oral administration of a spermidine-containing nutritional supplement once daily for 90 days can promote an extension of the anagen phase and reverse the transition from anagen to catagen and telogen phases. These effects are partly attributed to increased proliferation of hair bulb cells and reduced apoptosis.

Intake inversely correlates with obesity; supplementation cut weight and insulin resistance in DIO mice.

Spermidine enhances the expression of tyrosine hydroxylase by participating in the regulation of the melanogenesis factor MITF, indicating that spermidine may serve as a potential stimulant for melanin synthesis to prevent hair from turning gray. Computational analysis based on RNA sequencing data shows that spermidine can increase melanin production in melanocytes, making it a potential agent for alleviating pigmentation loss.
Research evidence on the substance Spermidine
The efficacy marked with * has been partially substantiated by research, and effects may vary among individuals.
Aging Internal & external red flags

· Body-shape anxiety


· Enlarged pores

· Weakened immunity

· Overall weakness

· Insomnia & dream-disturbed sleep

· Stress-related hair loss
Selection Criteria

INGREDIENT
50× efficacy, spermidine ≥ 54 %
Same raw material as DOUBLE WOOD, DoNotAge etc.
Low content, finished product ≈ 1 % spermidine
PURITY
Beige/off-white appearance
SAFETY
Product Profile

Spermidine

Authorized Factory
Certification
FDA, HACCP, GMP, ISO22000,
Hong Kong pharmaceutical qualifications


Spermidine
Suitable For
Adults 18+
Not Suitable For
Individuals under 18 years of age, pregnant or breastfeeding women. For other medical conditions, please consult a doctor.
Specifications
60 capsules/bottle
1 bottle ≈ 1-month supply
Formula (2 capsules per serving)
SuperMide™ Spermidine HCl
10mg
(Purity ≥ 98 %, spermidine ≥ 54 %)
Other Ingredients
Microcrystalline cellulose, Magnesium stearate, Gelatin capsules
Directions
2 capsules per day with meals
Shelf Life
24 months / 36 months
(Subject to the actual product received)
Storage
Keep in a cool, dry place, away from sunlight. Keep desiccant inside and tighten cap after opening.
Disclaimer
*The effects mentioned above are based on scientific research related to the ingredients, with references available upon request from our customer service.
Due to variations in production batches and manufacturing processes, there may be differences in the appearance of the product (such as capsules/tablets/form/colour), printing styles, and outer packaging. However, all products meet safety standards, so please rest assured.
Cautions
- Keep out of reach of children.
- Do not use if the safety seal is broken or missing.
- Consult your healthcare professional if you are pregnant or breastfeeding.
- If you are taking any medications or have any health concerns, it is advisable to consult your healthcare professional.
- This product is not intended to diagnose, treat, cure, or prevent any disease.
- This supplement should always be used in conjunction with a healthy diet and regular exercise program.
- Please refer to the supplement details page for ingredient information before purchasing; avoid use if you are allergic to any ingredients.
- Discontinue use if you experience any adverse effects.
- Do not take with medications.
Return Policy
If you are not completely satisfied with your purchase, please contact us via email. We will recommend the most suitable solution for you. Thanks to our adherence to industry-leading standards and UndoAge's quality assurance, customers rarely need to return products. However, if a return is necessary, rest assured that we will ensure a safe and hassle-free process.
We offer a 14-day worry-free refund guarantee for every order. Upholding our customer-first principle, we will:
- Provide a full refund for unopened products.
- For opened products (excluding powdered items), if the remaining quantity is ≥50%, you will receive a 50% refund.
Important Notes:
1. Return shipping costs must be borne by the customer.
2. To request a refund, please email
○ Order number
○ Photos of the product
○ Proof of purchase
○ Reason for return
Refund Processing Times:
1. Return review: up to 7 business days
2.Refund issuance: 7-14 business days after approval
Shipping information
Order processing time 1–2 business days; in-stock items ship immediately; pre-sale items ship according to the specified release dates
Reference for Regional Tax Standards
According to the Customs Tariff Policies of Various Countries, for products purchased personally by consumers, if customs duties are required, you will need to handle the payment yourself in accordance with the local laws and regulations.
Country / Territory | Duty-Free Allowances | Duty-Free Allowances (USD) | General Trade Import of Supplements / Dietary Supplements Import Duty Rates |
---|---|---|---|
Japan | JPY 100,000 | Approx $75.71 USD | 0% - 5% (depending on product) |
United States | None From May 2nd 2025, small parcels under $800 incur duties of 120% of value or $100 per item (whichever is higher); from June 1 2025, the flat fee rises to $200 per item. |
- | Import Duty: 145% (as of now) State Sales Tax: TBD |
Taiwan | TWD 2,000 | Approx $65.71 USD | 5% import duty + 5% business tax |
Canada | CAD 20 | Approx $15.71 USD | 0% import duty, but 5% - 15% GST/HST applies |
South Korea | USD 150 | - | 8% import duty + 10% VAT |
Singapore | SGD 400 | Approx $308.57 USD | 0% import duty, but 8% GST applies |
Australia | AUD 1,000 | Approx $671.43 USD | 0% import duty, but 10% GST applies |
Netherlands | EUR 150 – duty-free; EUR 22 – VAT-free |
Approx $162.86 USD, duty-free Approx $23.86 USD, VAT-free |
Import Duty: 9% Standard VAT: 21% |
Germany | • €45 – duty & VAT-free • €45 - €700 – flat 17.5% on declared value (excl. shipping) • >€700 – standard duties and VAT apply |
Approx $48.86 USD | • Up to €150 (~$162.86) tax-free; 19% VAT (7% on some goods) applies • Over €150 (~$162.86): 9% import duty + 19% VAT |
Italy | EUR 150 – duty-free; EUR 22 – VAT-free |
Approx $162.86 USD, duty-free Approx $23.86 USD, VAT-free |
0% - 17% import duty (depending on product) + 22% VAT |
France | EUR 150 | Approx $162.86 USD | 0% - 17% import duty (depending on product) + 20% VAT |
Spain | EUR 150 – duty-free; EUR 22 – VAT-free |
Approx $162.86 USD, duty-free Approx $23.86 USD, VAT-free |
0% - 17% import duty (depending on product) + 21% VAT |
New Zealand | NZD 60 | Approx $35.43 USD | 0% import duty + 15% VAT |
United Kingdom | GBP 135 – duty-free; GBP 15 – VAT-free |
Approx $177.43 USD | 0% - 17% import duty (depending on product) + 20% VAT |
Thailand | THB 1,000 | Approx $30.57 USD | 0% import duty + 7% VAT |
Indonesia | USD 3 | - | Imports under $3: duty-free + 11% VAT $3 - $1,500: 7.5% import duty + 11% VAT Over $1,500: Most-Favored-Nation rate (0% duty) + 5% - 15% VAT (12% for fish oil) |
Malaysia | RMB 5,000 | Approx $714.29 USD | 0% import duty |
Brazil | USD 50 – tax-free | - | Import Duty: 9% (simplified regime; goods valued $50 - $3,000 incur a flat 60% CIF-based duty) State Consumption Tax: 17% - 19% (simplified regime: 18% on CIF + import duty) |
Mexico | USD 50 – duty & VAT-free | - | 10% import duty + 16% VAT + 0.8% deferred tax on CIF + import duty |
Vietnam | VND 1,000,000 – duty-free | Approx $40.50 USD | 10% import duty + 10% VAT |
Hong Kong | RMB 12,000 | Approx $1,714.29 USD | 0% import duty + customs clearance fee (≤HK$46,000: HK$50.00; >HK$46,000: +HK$0.25 per additional HK$1,000 or fraction; fractions <HK$5: HK$0.10) |
Macau | RMB 12,000 | Approx $1,714.29 USD | 0% import duty |
Ireland | EUR 150 (duty on shipping ≤€10 exempt) EUR 22 (VAT on shipping ≤€6 exempt) |
Approx $162.86 USD, duty-free Approx $23.86 USD, VAT-free |
0% - 17% import duty (depending on product) + 23% VAT |
Austria | EUR 150 – duty-free; EUR 22 – VAT-free; combined duties & VAT ≤€10 exempt |
Approx $162.86 USD, duty-free Approx $23.86 USD, VAT-free |
0% - 17% import duty (depending on product) + 20% VAT |
Belgium | EUR 150 – duty-free; EUR 22 – VAT-free |
Approx $162.86 USD, duty-free Approx $23.86 USD, VAT-free |
0% - 17% import duty (depending on product) + 21% VAT |
Portugal | EUR 150 – duty-free; EUR 22 – VAT-free |
Approx $162.86 USD, duty-free Approx $23.86 USD, VAT-free |
0% - 17% import duty (depending on product) + 21% VAT |
Switzerland | CHF 5 – duty-free; CHF 5 – VAT-free |
Approx $5.88 USD | 133.4 PER/100 kg (fish oil) + 7.7% VAT |
Greece | EUR 150 – duty-free | Approx $162.86 USD | 0% - 17% import duty (depending on product) + 24% VAT |
Country / Territory | Duty-Free Allowances | General Trade Import of Supplements / Dietary Supplements Import Duty Rates |
---|---|---|
Japan |
Local Currency : JPY 100,000 USD : Approx $75.71 USD |
0% - 5% (depending on product) |
United States |
Local Currency : None From May 2nd 2025, small parcels under $800 incur duties of 120% of value or $100 per item (whichever is higher); from June 1 2025, the flat fee rises to $200 per item. USD : - |
Import Duty: 145% (as of now) State Sales Tax: TBD |
Taiwan |
Local Currency : TWD 2,000 USD : Approx $65.71 USD |
5% import duty + 5% business tax |
Canada |
Local Currency : CAD 20 USD : Approx $15.71 USD |
0% import duty, but 5% - 15% GST/HST applies |
South Korea |
Local Currency : USD 150 USD : - |
8% import duty + 10% VAT |
Singapore |
Local Currency : SGD 400 USD : Approx $308.57 USD |
0% import duty, but 8% GST applies |
Australia |
Local Currency : AUD 1,000 USD : Approx $671.43 USD |
0% import duty, but 10% GST applies |
Netherlands |
Local Currency : EUR 150 – duty-free; EUR 22 – VAT-free USD : Approx $162.86 USD, duty-free Approx $23.86 USD, VAT-free |
Import Duty: 9% Standard VAT: 21% |
Germany |
Local Currency : • €45 – duty & VAT-free • €45 - €700 – flat 17.5% on declared value (excl. shipping) • >€700 – standard duties and VAT apply USD : Approx $48.86 USD |
• Up to €150 (~$162.86) tax-free; 19% VAT (7% on some goods) applies • Over €150 (~$162.86): 9% import duty + 19% VAT |
Italy |
Local Currency : EUR 150 – duty-free; EUR 22 – VAT-free USD : Approx $162.86 USD, duty-free Approx $23.86 USD, VAT-free |
0% - 17% import duty (depending on product) + 22% VAT |
France |
Local Currency : EUR 150 USD : Approx $162.86 USD |
0% - 17% import duty (depending on product) + 20% VAT |
Spain |
Local Currency : EUR 150 – duty-free; EUR 22 – VAT-free USD : Approx $162.86 USD, duty-free Approx $23.86 USD, VAT-free |
0% - 17% import duty (depending on product) + 21% VAT |
New Zealand |
Local Currency : NZD 60 USD : Approx $35.43 USD |
0% import duty + 15% VAT |
United Kingdom |
Local Currency : GBP 135 – duty-free; GBP 15 – VAT-free USD : Approx $177.43 USD |
0% - 17% import duty (depending on product) + 20% VAT |
Thailand |
Local Currency : THB 1,000 USD : Approx $30.57 USD |
0% import duty + 7% VAT |
Indonesia |
Local Currency : USD 3 USD : - |
Imports under $3: duty-free + 11% VAT $3 - $1,500: 7.5% import duty + 11% VAT Over $1,500: Most-Favored-Nation rate (0% duty) + 5% - 15% VAT (12% for fish oil) |
Malaysia |
Local Currency : RMB 5,000 USD : Approx $714.29 USD |
0% import duty |
Brazil |
Local Currency : USD 50 – tax-free USD : - |
Import Duty: 9% (simplified regime; goods valued $50 - $3,000 incur a flat 60% CIF-based duty) State Consumption Tax: 17% - 19% (simplified regime: 18% on CIF + import duty) |
Mexico |
Local Currency : USD 50 – duty & VAT-free USD : - |
10% import duty + 16% VAT + 0.8% deferred tax on CIF + import duty |
Vietnam |
Local Currency : VND 1,000,000 – duty-free USD : Approx $40.50 USD |
10% import duty + 10% VAT |
Hong Kong |
Local Currency : RMB 12,000 USD : Approx $1,714.29 USD |
0% import duty + customs clearance fee (≤HK$46,000: HK$50.00; >HK$46,000: +HK$0.25 per additional HK$1,000 or fraction; fractions <HK$5: HK$0.10) |
Macau |
Local Currency : RMB 12,000 USD : Approx $1,714.29 USD |
0% import duty |
Ireland |
Local Currency : EUR 150 (duty on shipping ≤€10 exempt) EUR 22 (VAT on shipping ≤€6 exempt) USD : Approx $162.86 USD, duty-free Approx $23.86 USD, VAT-free |
0% - 17% import duty (depending on product) + 23% VAT |
Austria |
Local Currency : EUR 150 – duty-free; EUR 22 – VAT-free; combined duties & VAT ≤€10 exempt USD : Approx $162.86 USD, duty-free Approx $23.86 USD, VAT-free |
0% - 17% import duty (depending on product) + 20% VAT |
Belgium |
Local Currency : EUR 150 – duty-free; EUR 22 – VAT-free USD : Approx $162.86 USD, duty-free Approx $23.86 USD, VAT-free |
0% - 17% import duty (depending on product) + 21% VAT |
Portugal |
Local Currency : EUR 150 – duty-free; EUR 22 – VAT-free USD : Approx $162.86 USD, duty-free Approx $23.86 USD, VAT-free |
0% - 17% import duty (depending on product) + 21% VAT |
Switzerland |
Local Currency : CHF 5 – duty-free; CHF 5 – VAT-free USD : Approx $5.88 USD |
133.4 PER/100 kg (fish oil) + 7.7% VAT |
Greece |
Local Currency : EUR 150 – duty-free USD : Approx $162.86 USD |
0% - 17% import duty (depending on product) + 24% VAT |