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Spermidine
Spermidine
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2 capsules/day
As Low as
9.00 GBP/month
The following content is a scientific introduction to ingredient knowledge, representing only the effects of nutritional components and not serving as an introduction to the product's effects.
Scientific Evidence

Higher spermidine intake correlates with better cognition in mild-to-moderate dementia; mild cases benefit most.

Age-related spermidine decline impacts immunity; supplementation revives immune vigor via autophagy, translation and mitochondrial metabolism.

Randomized trial shows spermidine improves memory in elderly with cognitive decline, likely through neuromodulation.

In Dahl, salt-sensitive rats fed a high-salt diet, spermidine supplementation reduced systemic blood pressure and prevented cardiac hypertrophy and diastolic dysfunction, thereby delaying the progression to concentric heart failure. Data assessment indicates that high dietary levels of spermidine in humans are associated with lower blood pressure and a reduced incidence of cardiovascular disease.

Spermidine can upregulate the expression of epithelial stem cell-related keratins K15 and K19, as well as key target genes in human scalp hair follicles (HF) such as POP3 (which regulates cell adhesion and migration), SYVN1, NACA, and SLC25A3 (involved in endoplasmic reticulum and mitochondrial function). This demonstrates that spermidine is a potent stimulant for human hair growth and a modulator of human epithelial stem cell biology.
Oral administration of a spermidine-containing nutritional supplement once daily for 90 days can promote an extension of the anagen phase and reverse the transition from anagen to catagen and telogen phases. These effects are partly attributed to increased proliferation of hair bulb cells and reduced apoptosis.

Intake inversely correlates with obesity; supplementation cut weight and insulin resistance in DIO mice.

Spermidine enhances the expression of tyrosine hydroxylase by participating in the regulation of the melanogenesis factor MITF, indicating that spermidine may serve as a potential stimulant for melanin synthesis to prevent hair from turning gray. Computational analysis based on RNA sequencing data shows that spermidine can increase melanin production in melanocytes, making it a potential agent for alleviating pigmentation loss.
Research evidence on the substance Spermidine
The efficacy marked with * has been partially substantiated by research, and effects may vary among individuals.
Aging Internal & external red flags

· Body-shape anxiety


· Enlarged pores

· Weakened immunity

· Overall weakness

· Insomnia & dream-disturbed sleep

· Stress-related hair loss
Selection Criteria

INGREDIENT
50× efficacy, spermidine ≥ 54 %
Same raw material as DOUBLE WOOD, DoNotAge etc.
Low content, finished product ≈ 1 % spermidine
PURITY
Beige/off-white appearance
SAFETY
Product Profile

Spermidine

Authorized Factory
Certification
FDA, HACCP, GMP, ISO22000,
Hong Kong pharmaceutical qualifications


Spermidine
Suitable For
Adults 18+
Not Suitable For
Individuals under 18 years of age, pregnant or breastfeeding women. For other medical conditions, please consult a doctor.
Specifications
60 capsules/bottle
1 bottle ≈ 1-month supply
Formula (2 capsules per serving)
SuperMide™ Spermidine HCl
10mg
(Purity ≥ 98 %, spermidine ≥ 54 %)
Other Ingredients
Microcrystalline cellulose, Magnesium stearate, Gelatin capsules
Directions
2 capsules per day with meals
Shelf Life
24 months / 36 months
(Subject to the actual product received)
Storage
Keep in a cool, dry place, away from sunlight. Keep desiccant inside and tighten cap after opening.
Disclaimer
*The effects mentioned above are based on scientific research related to the ingredients, with references available upon request from our customer service.
Due to variations in production batches and manufacturing processes, there may be differences in the appearance of the product (such as capsules/tablets/form/colour), printing styles, and outer packaging. However, all products meet safety standards, so please rest assured.
Cautions
- Keep out of reach of children.
- Do not use if the safety seal is broken or missing.
- Consult your healthcare professional if you are pregnant or breastfeeding.
- If you are taking any medications or have any health concerns, it is advisable to consult your healthcare professional.
- This product is not intended to diagnose, treat, cure, or prevent any disease.
- This supplement should always be used in conjunction with a healthy diet and regular exercise program.
- Please refer to the supplement details page for ingredient information before purchasing; avoid use if you are allergic to any ingredients.
- Discontinue use if you experience any adverse effects.
- Do not take with medications.
Return Policy
If you are not completely satisfied with your purchase, please contact us via email. We will recommend the most suitable solution for you. Thanks to our adherence to industry-leading standards and UndoAge's quality assurance, customers rarely need to return products. However, if a return is necessary, rest assured that we will ensure a safe and hassle-free process.
We offer a 14-day worry-free refund guarantee for every order. Upholding our customer-first principle, we will:
- Provide a full refund for unopened products.
- For opened products (excluding powdered items), if the remaining quantity is ≥50%, you will receive a 50% refund.
Important Notes:
1. Return shipping costs must be borne by the customer.
2. To request a refund, please email
○ Order number
○ Photos of the product
○ Proof of purchase
○ Reason for return
Refund Processing Times:
1. Return review: up to 7 business days
2.Refund issuance: 7-14 business days after approval
Shipping information
Order processing time 1–2 business days; in-stock items ship immediately; pre-sale items ship according to the specified release dates